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Epilepsy and ovarian failure: Two cases of adolescent-onset ovarioleukodystrophy.

Clinical neurology and neurosurgery - 1 Feb 2018

Herrera-García José David, Guillen-Martínez Virginia, Creus-Fernández Carlota, Mínguez-Castellanos Adolfo, Carnero Pardo Cristóbal

Abstract excerpt

Vanishing white matter disease (VWM) was described by Van der Knaap in 1996. This association with premature ovarian failure is known as ovarioleukodystrophy. This is a rare entity caused by a mutation in one of the subunits of eukaryotic initiation factor 2B (EIF2B). The onset in adulthood or late in adolescence is very infrequent. A 41-years-old woman and her 37-years-old sister developed epilepsy in...

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Identifiers

PMID: 29331873
DOI: 10.1016/j.clineuro.2017.12.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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