A Genetic Investigation of Sex Bias in the Prevalence of Attention-Deficit/Hyperactivity Disorder.

doi:10.1016/j.biopsych.2017.11.026

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Article

A Genetic Investigation of Sex Bias in the Prevalence of Attention-Deficit/Hyperactivity Disorder.

Biological psychiatry - 15 Jun 2018

Martin Joanna, Walters Raymond K, Demontis Ditte, Mattheisen Manuel, Lee S Hong, Robinson Elise, Brikell Isabell, Ghirardi Laura, Larsson Henrik, Lichtenstein Paul, Eriksson Nicholas, Werge Thomas, Mortensen Preben Bo, Pedersen Marianne Giørtz, Mors Ole, Nordentoft Merete, Hougaard David M, Bybjerg-Grauholm Jonas, Wray Naomi R, Franke Barbara, Faraone Stephen V, O'Donovan Michael C, Thapar Anita, Børglum Anders D, Neale Benjamin M

Abstract excerpt

BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) shows substantial heritability and is two to seven times more common in male individuals than in female individuals. We examined two putative genetic mechanisms underlying this sex bias: sex-specific heterogeneity and higher burden of risk in female cases. METHODS: We analyzed genome-wide autosomal common variants from the Psychiatric Genomics Consortium...

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PMID: 29325848
DOI: 10.1016/j.biopsych.2017.11.026
PMCID: PMC5992329

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