Article
Causative Genes in Amyotrophic Lateral Sclerosis and Protein Degradation Pathways: a Link to Neurodegeneration.
Molecular neurobiology - 1 Aug 2018
Maurel C, Dangoumau A, Marouillat S, Brulard C, Chami A, Hergesheimer R, Corcia P, Blasco H, Andres C R, Vourc'h P
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a disease caused by the degeneration of motor neurons (MNs) leading to progressive muscle weakness and atrophy. Several molecular pathways have been implicated, such as glutamate-mediated excitotoxicity, defects in cytoskeletal dynamics and axonal transport, disruption of RNA metabolism, and impairments in proteostasis. ALS is associated with protein accumulation in the...
Topics
- Amyotrophic Lateral Sclerosis
- Animals
- Autophagy
- Genetic Predisposition to Disease
- Humans
- Nerve Degeneration
- Proteolysis
- Proteostasis