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Article

Emergence of insulin resistance following empirical glibenclamide therapy: a case report of neonatal diabetes with a recessive INS gene mutation.

Journal of pediatric endocrinology & metabolism : JPEM - 28 Mar 2018

Yildiz Melek, Akcay Teoman, Aydin Banu, Akgun Abdurrahman, Dogan Beyza Belde, De Franco Elisa, Ellard Sian, Onal Hasan

Abstract excerpt

BACKGROUND: As KATP channel mutations are the most common cause of neonatal diabetes mellitus (NDM) and patients with these mutations can be treated with oral sulfonylureas, empiric therapy is a common practice for NDM patients. CASE PRESENTATION: A non-syndromic, small for gestational age baby born to first-degree consanguineous parents was diagnosed with NDM. Because of hypo- and hyperglycemic episodes and...

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Source

Identifiers

PMID: 29305569
DOI: 10.1515/jpem-2017-0325

Genes

INS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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