Article
Three cases of permanent neonatal diabetes mellitus: genotypes and management outcome.
Singapore medical journal - 1 Jul 2012
Ooi Hooi Leng, Wu Loo Ling
Abstract excerpt
Neonatal diabetes mellitus (DM) is defined as insulin-requiring DM in the first six months of life. Unlike type 1 DM, it is a monogenic disorder resulting from a de novo mutation in the genes involved in the development of the pancreas, β-cell mass or secretory function. The majority of neonatal DM cases are caused by a heterozygous activating mutation in the KCNJ11 or ABCC8 genes that encode the Kir6.2 and SUR1...
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