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In vitro differentiation of human oocyte-like cells from oogonial stem cells: single-cell isolation and molecular characterization

18 Dec 2017

Abstract excerpt

STUDY QUESTION: Are the large cells derived from cultured DEAD box polypeptide 4 (DDX4)-positive oogonial stem cells (OSCs), isolated from the ovarian cortex of non-menopausal and menopausal women, oocyte-like cells? SUMMARY ANSWER: Under appropriate culture conditions, DDX4-positive OSCs from non-menopausal and menopausal women differentiate into large haploid oocyte-like cells expressing the major oocyte...

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PMID: 29304224
DOI: 10.1093/humrep/dex377

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