Article
[A boy with digital clubbing].
Nederlands tijdschrift voor geneeskunde - 1 Jan 2000
Van de Ven A, Klaassens M
Abstract excerpt
A 4-year-old boy was referred because of pan-digital clubbing and watch-glass nails. Other remarkable findings were: surgical closure of a patent arterial duct, decreased knee-mobility and consanguineous parents. This combination is suggestive for primary hypertrophic osteoarthropathy (PHO; #OMIM 259100). PHO was proven by his homozygous mutation of the 15-hydroxyprostaglandine dehydroxygenase-gene.
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