Article
Complete form of pachydermoperiostosis: a case report.
Dermatology online journal - 15 Feb 2013
Chander Ram, Kakkar Sushil, Jain Arpita, Barara Meenu, Agarwal Kiran, Varghese Bincy
Abstract excerpt
Pachydermoperiostosis is a primary form of hypertrophic osteoarthropathy, which presents with pachydermia, digital clubbing, and radiologic periostosis. Pachydermoperiostosis occurs owing to mutations of the gene encoding for 15-hydroxyprostaglandin dehydrogenase (15HPGD). Clinical manifestations of PDP are thought to relate to excessive collagen formation and dysregulation of matrix proteins because of...
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