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Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 714 adults from Colombo, Sri Lanka.

Human immunology - 1 Feb 2018

Grifoni Alba, Weiskopf Daniela, Lindestam Arlehamn Cecilia S, Angelo Michael, Leary Shay, Sidney John, Frazier April, Phillips Elizabeth, Mallal Simon, Mack Steven J, Tippalagama Rashmi, Goonewardana Suraj, Premawansa Sunil, Premawansa Gayani, Wijewickrama Ananda, De Silva Aruna D, Sette Alessandro

Abstract excerpt

DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, and -DRB1 loci was performed on 714 healthy adult blood bank donors from Colombo, Sri Lanka, to characterize allele frequencies in support of studies on T cell immunity against pathogens, including Dengue virus. Deviations from Hardy Weinberg proportions were not detected at any locus. Several alleles were found in >30% of individuals, including...

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PMID: 29289740
DOI: 10.1016/j.humimm.2017.12.007
PMCID: PMC6378951

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