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Article

Nuclear Androgen Receptor Regulates Testes Organization and Oocyte Maturation in Zebrafish

19 Dec 2017

Abstract excerpt

Androgens act through the nuclear androgen receptor (AR) to regulate gonad differentiation and development. In mice, AR is necessary for spermatogenesis, testis development, and formation of external genitalia in males and oocyte maturation in females. However, the extent to which these phenotypes are conserved in nonmammalian vertebrates is not well understood. Here, we generate zebrafish with a mutation in the...

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PMID: 29272351
DOI: 10.1210/en.2017-00617

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