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Article

Clinical Implications of the Autophagy Core Gene Variations in Advanced Lung Adenocarcinoma Treated with Gefitinib.

Scientific reports - 19 Dec 2017

Yuan Jupeng, Zhang Nasha, Yin Longbin, Zhu Hui, Zhang Li, Zhou Liqing, Yang Ming

Abstract excerpt

EGFR-TKIs show dramatic treatment benefits for advanced lung adenocarcinoma patients with activating EGFR mutations. Considering the essential role of autophagy in EGFR-TKIs treatments, we hypothesized that genetic variants in autophagy core genes might contribute to outcomes of advanced lung adenocarcinoma treated with gefitinib. We systematically examined 27 potentially functional genetic polymorphisms in 11...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29259263
DOI: 10.1038/s41598-017-18165-5
PMCID: PMC5736620

Genes

ATG10
EGFR
ATG5
ATG12
ATG7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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