Article
Retiring the term FTDP-17 as MAPT mutations are genetic forms of sporadic frontotemporal tauopathies.
Brain : a journal of neurology - 1 Feb 2018
Forrest Shelley L, Kril Jillian J, Stevens Claire H, Kwok John B, Hallupp Marianne, Kim Woojin S, Huang Yue, McGinley Ciara V, Werka Hellen, Kiernan Matthew C, Götz Jürgen, Spillantini Maria Grazia, Hodges John R, Ittner Lars M, Halliday Glenda M
Abstract excerpt
See Josephs (doi:10.1093/brain/awx367) for a scientific commentary on this article.In many neurodegenerative disorders, familial forms have provided important insights into the pathogenesis of their corresponding sporadic forms. The first mutations associated with frontotemporal lobar degeneration (FTLD) were found in the microtubule-associated protein tau (MAPT) gene on chromosome 17 in families with...
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