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Age is the work of art? Impact of neutrophil and organism age on neutrophil extracellular trap formation

18 Dec 2017

Abstract excerpt

Neutrophil extracellular traps or NETs are released by highly activated neutrophils in response to infectious agents, sterile inflammation, autoimmune stimuli and cancer. In the cells, the nuclear envelop disintegrates and decondensation of chromatin occurs that depends on peptidylarginine deiminase 4 (PAD4) and neutrophil elastase (NE). Subsequently, proteins from neutrophil granules (e.g., NE, lactoferrin and...

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PMID: 29250748
DOI: 10.1007/s00441-017-2751-4

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