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Article

Impaired IFNγ-Signaling and Mycobacterial Clearance in IFNγR1-Deficient Human iPSC-Derived Macrophages.

Stem cell reports - 9 Jan 2018

Neehus Anna-Lena, Lam Jenny, Haake Kathrin, Merkert Sylvia, Schmidt Nico, Mucci Adele, Ackermann Mania, Schubert Madline, Happle Christine, Kühnel Mark Philipp, Blank Patrick, Philipp Friederike, Goethe Ralph, Jonigk Danny, Martin Ulrich, Kalinke Ulrich, Baumann Ulrich, Schambach Axel, Roesler Joachim, Lachmann Nico

Abstract excerpt

Mendelian susceptibility to mycobacterial disease (MSMD) is caused by inborn errors of interferon gamma (IFNγ) immunity and is characterized by severe infections by weakly virulent mycobacteria. Although IFNγ is the macrophage-activating factor, macrophages from these patients have never been studied. We demonstrate the generation of heterozygous and compound heterozygous (iMSMD-cohet) induced pluripotent stem...

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Identifiers

PMID: 29249666
DOI: 10.1016/j.stemcr.2017.11.011
PMCID: PMC5768914

Genes

STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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