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Article

Integration-free induced pluripotent stem cells derived from a patient with autosomal recessive Alport syndrome (ARAS).

Stem cell research - 1 Dec 2017

Kuebler Bernd, Aran Begoña, Miquel-Serra Laia, Muñoz Yolanda, Ars Elisabet, Bullich Gemma, Furlano Monica, Torra Roser, Marti Merce, Veiga Anna, Raya Angel

Abstract excerpt

A skin biopsy was obtained from a 25-year-old female patient with autosomal recessive Alport syndrome (ARAS) with the homozygous COL4A3 mutation c.345delG, p.(P166Lfs*37). Dermal fibroblasts were derived and reprogrammed by nucleofection with episomal plasmids carrying OCT3/4, SOX2, KLF4 LIN28, L-MYC and p53shRNA. The generated induced Pluripotent Stem Cell (iPSC) clone AS FiPS1 Ep6F-2 was free of genomically...

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Identifiers

PMID: 29246570
DOI: 10.1016/j.scr.2017.08.021

Genes

KLF4
MYC
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Integration-free induced pluripotent stem cells derived from a patient with autosomal recessive Alport syndrome (ARAS).PMID 29246570Read ↗

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