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mcr-3 and mcr-4 Variants in Carbapenemase-Producing Clinical Enterobacteriaceae Do Not Confer Phenotypic Polymyxin Resistance

13 Dec 2017

Abstract excerpt

The worldwide distribution of plasmid-mediated colistin resistance determinants (mcr-1, mcr-2, mcr-3, and mcr-4) coupled to the emerging observation that colistin resistance is more prevalent in carbapenem-resistant Enterobacteriaceae (CRE) (1, 2) presents a daunting challenge in combatting antimicrobial resistance. Undoubtedly, next-generation sequencing approaches have expedited the discovery of mobile colistin...

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PMID: 29237785
DOI: 10.1128/jcm.01562-17

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