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Article

Analyzing metabolomics data for association with genotypes using two-component Gaussian mixture distributions.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2018

Westra Jason, Hartman Nicholas, Lake Bethany, Shearer Gregory, Tintle Nathan

Abstract excerpt

Standard approaches to evaluate the impact of single nucleotide polymorphisms (SNP) on quantitative phenotypes use linear models. However, these normal-based approaches may not optimally model phenotypes which are better represented by Gaussian mixture distributions (e.g., some metabolomics data). We develop a likelihood ratio test on the mixing proportions of two-component Gaussian mixture distributions and...

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PMID: 29218908
PMCID: PMC5757879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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