Article
Non-driver mutations in patients with JAK2V617F-mutated polycythemia vera or essential thrombocythemia with long-term molecular follow-up.
Annals of hematology - 1 Mar 2018
Senín Alicia, Fernández-Rodríguez Concepción, Bellosillo Beatriz, Camacho Laura, Longarón Raquel, Angona Anna, Besses Carles, Álvarez-Larrán Alberto
Abstract excerpt
JAK2V617F monitoring and NGS of non-driver genes was performed in 100 patients with polycythemia vera (PV) or essential thrombocythemia (ET) with long molecular follow-up. Patients who did not progress to myelofibrosis (MF) or acute myeloid leukemia (AML) after more than 10 years (n = 50) showed a low frequency of mutations at first sample (18%) and an incidence rate of 1.7 new mutations × 100 person-years....
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