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Article

Effect of Calcium-Infiltrated Hydroxyapatite Scaffolds on the Hematopoietic Fate of Human Umbilical Vein Endothelial Cells.

Journal of vascular research - 1 Jan 2017

Zhang Qinghao, Gerlach Jörg C, Schmelzer Eva, Nettleship Ian

Abstract excerpt

Foamed hydroxyapatite offers a three-dimensional scaffold for the development of bone constructs, mimicking perfectly the in vivo bone structure. In vivo, calcium release at the surface is assumed to provide a locally increased gradient supporting the maintenance of the hematopoietic stem cells niche. We fabricated hydroxyapatite scaffolds with high surface calcium concentration by infiltration, and used human...

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Identifiers

PMID: 29166642
DOI: 10.1159/000481778
PMCID: PMC5720900

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