Article
Germline variation in ADAMTSL1 is associated with prognosis following breast cancer treatment in young women.
Nature communications - 21 Nov 2017
Kadalayil Latha, Khan Sofia, Nevanlinna Heli, Fasching Peter A, Couch Fergus J, Hopper John L, Liu Jianjun, Maishman Tom, Durcan Lorraine, Gerty Sue, Blomqvist Carl, Rack Brigitte, Janni Wolfgang, Collins Andrew, Eccles Diana, Tapper William
Abstract excerpt
To identify genetic variants associated with breast cancer prognosis we conduct a meta-analysis of overall survival (OS) and disease-free survival (DFS) in 6042 patients from four cohorts. In young women, breast cancer is characterized by a higher incidence of adverse pathological features, unique gene expression profiles and worse survival, which may relate to germline variation. To explore this hypothesis, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.