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Article

Genetic biomarkers associated with pain flare and dexamethasone response following palliative radiotherapy in patients with painful bone metastases.

Annals of palliative medicine - 1 Dec 2017

Furfari Anthony, Wan Bo Angela, Ding Keyue, Wong Andrew, Zhu Liting, Bezjak Andrea, Wong Rebecca, Wilson Carolyn F, DeAngelis Carlo, Azad Azar, Chow Edward, Charames George S

Abstract excerpt

BACKGROUND: In patients who receive palliative radiation therapy (RT) for painful bone metastases, 40% experience a transient increase in pain known as a pain flare. Prophylactic dexamethasone has been shown to reduce pain flare incidence to 25%. We aimed to identify DNA biomarkers associated with pain flare and dexamethasone response. METHODS: Daily pain levels were recorded by 81 patients who received a single...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29156912
DOI: 10.21037/apm.2017.09.04

Genes

DNM2
NBPF1
ADAMTS16
DHODH
HAS1
PECR
TSEN54
VLDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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