Equine herpesvirus type 1 ORF51 encoding UL11 as an essential gene for replication in cultured cells.

doi:10.1007/s00705-017-3650-4

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Article

Equine herpesvirus type 1 ORF51 encoding UL11 as an essential gene for replication in cultured cells.

Archives of virology - 1 Mar 2018

Badr Yassien, Okada Ayaka, Abo-Sakaya Rania, Beshir Emad, Ohya Kenji, Fukushi Hideto

Abstract excerpt

Equine herpesvirus type 1 (EHV-1) UL11 is a 74-amino-acid tegument protein encoded by ORF51 of the EHV-1 genome. EHV-1 UL11 was previously reported by other researchers using the RacL22 and RacH strains to be nonessential for viral replication in cultured cells. Here, we constructed UL11 mutant viruses including a UL11 null mutant and three C-terminal truncated mutants, for further characterization of EHV-1 UL11...

Topics

Animals
Base Sequence
Cell Line
Cell Nucleus
Chromosomes, Artificial, Bacterial
Epithelial Cells
Gene Expression
Golgi Apparatus
Herpesvirus 1, Equid
Horses
Kidney
Mutation
Open Reading Frames
Rabbits
Viral Structural Proteins
Virulence
Virus Replication

Source

Open in PubMed

Identifiers

PMID: 29149435
DOI: 10.1007/s00705-017-3650-4

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