Article
Mouse Models of Achromatopsia in Addressing Temporal "Point of No Return" in Gene-Therapy.
International journal of molecular sciences - 28 Jul 2021
Wang Nan-Kai, Liu Pei-Kang, Kong Yang, Levi Sarah R, Huang Wan-Chun, Hsu Chun-Wei, Wang Hung-Hsi, Chen Nelson, Tseng Yun-Ju, Quinn Peter M J, Tai Ming-Hong, Lin Chyuan-Sheng, Tsang Stephen H
Abstract excerpt
Achromatopsia is characterized by amblyopia, photophobia, nystagmus, and color blindness. Previous animal models of achromatopsia have shown promising results using gene augmentation to restore cone function. However, the optimal therapeutic window to elicit recovery remains unknown. Here, we attempted two rounds of gene augmentation to generate recoverable mouse models of achromatopsia including a Cnga3 model...
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