Article
Dystonia-4 (DYT4)-associated TUBB4A mutants exhibit disorganized microtubule networks and inhibit neuronal process growth.
Biochemical and biophysical research communications - 1 Jan 2018
Watanabe Natsumi, Itakaoka Misa, Seki Yoich, Morimoto Takako, Homma Keiichi, Miyamoto Yuki, Yamauchi Junji
Abstract excerpt
Dystonia-1 (DYT1) is an autosomal dominant early-onset torsion form of dystonia, a neurological disease affecting movement. DYT1 is the prototypic hereditary dystonia and is caused by the mutation of the tor1a gene. The gene product has chaperone functions important for the control of protein folding and stability. Dystonia-4 (DYT4) is another autosomal dominant dystonia that is characterized by onset in the...
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