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Article

Understanding the roles of mutations in the amyloid precursor protein in Alzheimer disease.

Molecular psychiatry - 1 Jan 2018

Hunter S, Brayne C

Abstract excerpt

Many models of disease progression in Alzheimer's disease (AD) have been proposed to help guide experimental design and aid the interpretation of results. Models focussing on the genetic evidence include the amyloid cascade (ACH) and presenilin (PSH) hypotheses and the amyloid precursor protein (APP) matrix approach (AMA), of which the ACH has held a dominant position for over two decades. However, the ACH has...

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Identifiers

PMID: 29112196
DOI: 10.1038/mp.2017.218

Genes

APP

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