Article
Combined microRNA and mRNA expression analysis in pediatric multiple sclerosis: an integrated approach to uncover novel pathogenic mechanisms of the disease.
Human molecular genetics - 1 Jan 2018
Liguori Maria, Nuzziello Nicoletta, Licciulli Flavio, Consiglio Arianna, Simone Marta, Viterbo Rosa Gemma, Creanza Teresa Maria, Ancona Nicola, Tortorella Carla, Margari Lucia, Grillo Giorgio, Giordano Paola, Liuni Sabino, Trojano Maria
Abstract excerpt
Multiple sclerosis (MS) is a complex disease of the CNS that usually affects young adults, although 3-5% of cases are diagnosed in childhood and adolescence (hence called pediatric MS, PedMS). Genetic predisposition, among other factors, seems to contribute to the risk of the onset, in pediatric as in adult ages, but few studies have investigated the genetic 'environmentally naïve' load of PedMS. The main goal of...
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