Location of Mutation in BRCA2 Gene and Survival in Patients with Ovarian Cancer.

doi:10.1158/1078-0432.CCR-17-2136

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Article

Location of Mutation in BRCA2 Gene and Survival in Patients with Ovarian Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2018

Labidi-Galy S Intidhar, Olivier Timothée, Rodrigues Manuel, Ferraioli Domenico, Derbel Olfa, Bodmer Alexandre, Petignat Patrick, Rak Beata, Chopin Nicolas, Tredan Olivier, Heudel Pierre-Etienne, Stuckelberger Sarah, Meeus Pierre, Meraldi Patrick, Viassolo Valeria, Ayme Aurélie, Chappuis Pierre O, Stern Marc-Henri, Houdayer Claude, Stoppa-Lyonnet Dominique, Buisson Adrien, Golmard Lisa, Bonadona Valérie, Ray-Coquard Isabelle

Abstract excerpt

Purpose: BRCA2 plays a central role in homologous recombination by loading RAD51 on DNA breaks. The objective of this study is to determine whether the location of mutations in the RAD51-binding domain (RAD51-BD; exon 11) of BRCA2 gene affects the clinical outcome of ovarian cancer patients.Experimental Design: A study cohort of 353 women with ovarian cancer who underwent genetic germline testing for BRCA1 and...

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Identifiers

PMID: 29084914
DOI: 10.1158/1078-0432.CCR-17-2136

Genes

BRCA2
RAD51
BRCA1

Provenance

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Source receipt: pubmed, retrieved 6 Sept 2026.

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