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Article

Estimated allele substitution effects underlying genomic evaluation models depend on the scaling of allele counts.

Genetics, selection, evolution : GSE - 30 Oct 2017

Bouwman Aniek C, Hayes Ben J, Calus Mario P L

Abstract excerpt

BACKGROUND: Genomic evaluation is used to predict direct genomic values (DGV) for selection candidates in breeding programs, but also to estimate allele substitution effects (ASE) of single nucleotide polymorphisms (SNPs). Scaling of allele counts influences the estimated ASE, because scaling of allele counts results in less shrinkage towards the mean for low minor allele frequency (MAF) variants. Scaling may...

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PMID: 29084514
DOI: 10.1186/s12711-017-0355-9
PMCID: PMC5662034

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MAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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