Article
Hyperoxia causes miR-34a-mediated injury via angiopoietin-1 in neonatal lungs.
Nature communications - 27 Oct 2017
Syed Mansoor, Das Pragnya, Pawar Aishwarya, Aghai Zubair H, Kaskinen Anu, Zhuang Zhen W, Ambalavanan Namasivayam, Pryhuber Gloria, Andersson Sture, Bhandari Vineet
Abstract excerpt
Hyperoxia-induced acute lung injury (HALI) is a key contributor to the pathogenesis of bronchopulmonary dysplasia (BPD) in neonates, for which no specific preventive or therapeutic agent is available. Here we show that lung micro-RNA (miR)-34a levels are significantly increased in lungs of neonatal mice exposed to hyperoxia. Deletion or inhibition of miR-34a improves the pulmonary phenotype and BPD-associated...
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