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On the origin and impact of mesenchymal stem cell heterogeneity: new insights and emerging tools for single cell analysis

27 Oct 2017

Abstract excerpt

Mesenchymal stem cells (MSCs) display substantial cell-to-cell variation. This heterogeneity manifests among donors, among tissue sources, and within cell populations. Such pervasive variability complicates the use of MSCs in regenerative applications and may limit their therapeutic efficacy. Most conventional assays measure MSC properties in bulk and, as a consequence, mask this cell-to-cell variation. Recent...

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PMID: 29076514
DOI: 10.22203/ecm.v034a14

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