Impairment of elastic properties of the aorta in bicuspid aortic valve: relationship between biomolecular and aortic strain patterns.

doi:10.1093/ehjci/jex224

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Article

Impairment of elastic properties of the aorta in bicuspid aortic valve: relationship between biomolecular and aortic strain patterns.

European heart journal. Cardiovascular Imaging - 1 Aug 2018

Longobardo Luca, Carerj Maria Ludovica, Pizzino Gabriele, Bitto Alessandra, Piccione Maurizio Cusma, Zucco Marta, Oreto Lilia, Todaro Maria Chiara, Calabrò Maria Pia, Squadrito Francesco, Di Bella Gianluca, Oreto Giuseppe, Khandheria Bijoy K, Carerj Scipione, Zito Concetta

Abstract excerpt

Aims: Bicuspid aortic valve (BAV) is associated with aortic wall alterations. We aimed to detect any correlation between aortic elasticity and genetic and biomolecular patterns of elastin. Methods and results: Forty-nine BAV patients (mean age: 38 ± 17.05) were prospectively enrolled. A blood sample was drawn for analysis of a single nucleotide polymorphism of elastin gene (ELN rs2071307) responsible for...

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PMID: 29029085
DOI: 10.1093/ehjci/jex224

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