Article
Penetrance of a rare familial mutation predisposing to papillary thyroid cancer.
Familial cancer - 1 Jul 2018
Saporito Donika, Brock Pamela, Hampel Heather, Sipos Jennifer, Fernandez Soledad, Liyanarachchi Sandya, de la Chapelle Albert, Nagy Rebecca
Abstract excerpt
Familial non-medullary thyroid cancer (FNMTC) is clinically defined as two or more first-degree relatives with NMTC and appears to follow an autosomal dominant inheritance pattern. Approximately 5-7% of NMTC is hereditary and affects multiple generations with a young age of onset. The primary aim of this study was to determine the age-specific penetrance of NMTC in individuals from a large family with FNMTC with...
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