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Article

Rescue of Outer Hair Cells with Antisense Oligonucleotides in Usher Mice Is Dependent on Age of Treatment.

Journal of the Association for Research in Otolaryngology : JARO - 1 Feb 2018

Ponnath Abhilash, Depreux Frederic F, Jodelka Francine M, Rigo Frank, Farris Hamilton E, Hastings Michelle L, Lentz Jennifer J

Abstract excerpt

The absence of functional outer hair cells is a component of several forms of hereditary hearing impairment, including Usher syndrome, the most common cause of concurrent hearing and vision loss. Antisense oligonucleotide (ASO) treatment of mice with the human Usher mutation, Ush1c c.216G>A, corrects gene expression and significantly improves hearing, as measured by auditory-evoked brainstem responses (ABRs), as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Evoked Potentials, Auditory, Brain Stem

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Share to Oligonucleotides, Antisense

Share to Otoacoustic Emissions, Spontaneous

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Identifiers

PMID: 29027038
DOI: 10.1007/s10162-017-0640-x
PMCID: PMC5783922

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ABR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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