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Article

P38/ERK MAPK signaling pathways are involved in the regulation of filaggrin and involucrin by IL-17

2 Oct 2017

Abstract excerpt

Atopic dermatitis (AD) is characterized by a defective skin barrier, which increases the penetration of allergens and pathogens through the skin. The role of interleukin (IL)‑17, a pro‑inflammatory cytokine, in the pathogenesis of AD remains to be elucidated. The present study aimed to examine the effects of IL‑17 on skin barrier proteins in the HaCaT cell line. The expression levels of filaggrin (FLG) and...

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Share to Allergic Rhinitis and Sensitization
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Identifiers

PMID: 28990053
DOI: 10.3892/mmr.2017.7689

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