Article
A potentially crucial role of the PKD1 C-terminal tail in renal prognosis.
Clinical and experimental nephrology - 1 Apr 2018
Higashihara Eiji, Horie Shigeo, Kinoshita Moritoshi, Harris Peter C, Okegawa Takatsugu, Tanbo Mitsuhiro, Hara Hidehiko, Yamaguchi Tsuyoshi, Shigemori Kaori, Kawano Haruna, Miyazaki Isao, Kaname Shinya, Nutahara Kikuo
Abstract excerpt
BACKGROUND: Autosomal dominant polycystic disease (ADPKD) often results in renal failure. Recently, allelic influences of PKD1 mutation types on renal survival were extensively investigated. Here, we analyzed integrated influences of PKD1 mutation types and positions on renal survival. METHODS: We included 338 (82 pedigrees) and 72 (12 pedigrees) patients with PKD1 and PKD2 mutations, respectively, identified...
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