Article
A study of PD-L1 expression in KRAS mutant non-small cell lung cancer cell lines exposed to relevant targeted treatments.
PloS one - 1 Jan 2017
Minchom Anna, Thavasu Parames, Ahmad Zai, Stewart Adam, Georgiou Alexandros, O'Brien Mary E R, Popat Sanjay, Bhosle Jaishree, Yap Timothy A, de Bono Johann, Banerji Udai
Abstract excerpt
We investigated PD-L1 changes in response to MEK and AKT inhibitors in KRAS mutant lung adenocarcinoma (adeno-NSCLC). PD-L1 expression was quantified using immunofluorescence and co-culture with a jurkat cell-line transfected with NFAT-luciferase was used to study if changes in PD-L1 expression in cancer cell lines were functionally relevant. Five KRAS mutant cell lines with high PD-L1 expression (H441, H2291,...
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