Article
Prenatal Diagnosis of Resistance to Thyroid Hormone and Its Clinical Implications.
The Journal of clinical endocrinology and metabolism - 1 Oct 2017
Pappa Theodora, Anselmo João, Mamanasiri Sunnee, Dumitrescu Alexandra M, Weiss Roy E, Refetoff Samuel
Abstract excerpt
Context: Resistance to thyroid hormone-β (RTH-β) is an autosomal dominant disorder characterized by reduced sensitivity of target tissues to thyroid hormones (THs). Individuals with RTH-β have high TH levels usually due to mutations in the TH receptor-β (THRB) gene. The management of RTH-β during pregnancy is challenging, as wild-type (WT) fetuses born to RTH-β mothers have low birth weight and suppressed...
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