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Efficacy of recombinant measles virus expressing highly pathogenic avian influenza virus (HPAIV) antigen against HPAIV infection in monkeys.

Scientific reports - 20 Sept 2017

Fujiyuki Tomoko, Horie Ryo, Yoneda Misako, Kuraishi Takeshi, Yasui Fumihiko, Kwon Hyun-Jeong, Munekata Keisuke, Ikeda Fusako, Hoshi Miho, Kiso Yuri, Omi Mio, Sato Hiroki, Kida Hiroshi, Hattori Shosaku, Kohara Michinori, Kai Chieko

Abstract excerpt

Highly pathogenic avian influenza virus (HPAIV) is a serious threat not only to domestic fowls but also to humans. Vaccines inducing long-lasting immunity against HPAIV are required. In the present study, we generated recombinant measles virus (MV) expressing the hemagglutinin protein of HPAIV without the multibasic site necessary for its pathogenicity in chickens using the backbone of an MV vaccine strain...

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Identifiers

PMID: 28931922
DOI: 10.1038/s41598-017-08326-x
PMCID: PMC5607339

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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