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Simulation of early DNA damage after the irradiation of a fibroblast cell nucleus using Geant4-DNA

14 Sept 2017

Abstract excerpt

In order to improve the understanding of the mechanisms involved in the generation of early DNA damage, a new calculation chain based on the Geant4-DNA toolkit was developed. This work presents for the first time the simulation of the physical, physicochemical and chemical stages of early radiation damage at the scale of an entire human genome (fibroblast, male) and using Geant4-DNA models. The DnaFabric software...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28931851
DOI: 10.1038/s41598-017-11851-4

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