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Article

Influence of chromatin compaction on simulated early radiation‐induced DNA damage using Geant4‐ DNA

28 Jan 2019

Abstract excerpt

PURPOSE: In this work, we present simulated double-strand breaks (DSBs) obtained for two human cell nucleus geometries. The first cell nucleus represents fibroblasts, filled with DNA molecules in different compaction forms: heterochromatin or euchromatin only. The second one represents an endothelial cell nucleus, either filled with heterochromatin only or with a uniform distribution of 48% of heterochromatin and...

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PMID: 30689203
DOI: 10.1002/mp.13405

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