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Article

Structurally Guided Removal of DeISGylase Biochemical Activity from Papain-Like Protease Originating from Middle East Respiratory Syndrome Coronavirus.

Journal of virology - 1 Dec 2017

Daczkowski Courtney M, Goodwin Octavia Y, Dzimianski John V, Farhat Jonathan J, Pegan Scott D

Abstract excerpt

Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging human pathogen that is the causative agent for Middle East respiratory syndrome (MERS). With MERS outbreaks resulting in over 35% fatalities and now spread to 27 countries, MERS-CoV poses a significant ongoing threat to global human health. As part of its viral genome, MERS-CoV encodes a papain-like protease (PLpro) that has been observed to...

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Identifiers

PMID: 28931677
DOI: 10.1128/JVI.01067-17
PMCID: PMC5686735

Genes

ISG15

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Structurally Guided Removal of DeISGylase Biochemical Activity from Papain-Like Protease Originating from Middle East Respiratory Syndrome Coronavirus.PMID 28931677Read ↗

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