Multiparameter Investigation of a 46,XX/46,XY Tetragametic Chimeric Phenotypical Male Patient with Bilateral Scrotal Ovotestes and Ovulatory Activity.

doi:10.1159/000479946

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Article

Multiparameter Investigation of a 46,XX/46,XY Tetragametic Chimeric Phenotypical Male Patient with Bilateral Scrotal Ovotestes and Ovulatory Activity.

Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation - 1 Jan 2018

van Bever Yolande, Wolffenbuttel Katja P, Brüggenwirth Hennie T, Blom Eric, de Klein Annelies, Eussen Bert H J, van der Windt Florijn, Hannema Sabine E, Dessens Arianne B, Dorssers Lambert C J, Biermann Katharina, Hersmus Remko, de Rijke Yolanda B, Looijenga Leendert H J

Abstract excerpt

We report on an adult male initially presenting with gynecomastia and a painless scrotal mass without additional genital anomalies. Hyperpigmentation of the skin following the Blaschko's lines was identified. He underwent gonadectomy because of suspected cancer. Histological analyses revealed an ovotestis with ovulatory activity confirmed by immunohistochemistry with multiple markers. Karyotyping of cultured...

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PMID: 28926831
DOI: 10.1159/000479946
PMCID: PMC5872565

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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