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Article

Low-gluten, nontransgenic wheat engineered with CRISPR/Cas9.

Plant biotechnology journal - 1 Apr 2018

Sánchez-León Susana, Gil-Humanes Javier, Ozuna Carmen V, Giménez María J, Sousa Carolina, Voytas Daniel F, Barro Francisco

Abstract excerpt

Coeliac disease is an autoimmune disorder triggered in genetically predisposed individuals by the ingestion of gluten proteins from wheat, barley and rye. The α-gliadin gene family of wheat contains four highly stimulatory peptides, of which the 33-mer is the main immunodominant peptide in patients with coeliac. We designed two sgRNAs to target a conserved region adjacent to the coding sequence for the 33-mer in...

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Identifiers

PMID: 28921815
DOI: 10.1111/pbi.12837
PMCID: PMC5867031

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