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Article

Analysis of the genes involved in Mendelian forms of low-renin hypertension in Chinese early-onset hypertensive patients.

Journal of hypertension - 1 Mar 2018

Liu Kai, Qin Fang, Sun Xiaolu, Zhang Yang, Wang Jizheng, Wu Yajie, Ma Wenjun, Wang Wei, Wu Xueyi, Qin Ying, Zhang Huimin, Zhou Xianliang, Wu Haiying, Hui Rutai, Zou Yubao, Jiang Xiongjing, Song Lei

Abstract excerpt

BACKGROUND: The study aimed to analyze genes involved in Mendelian forms of low-renin hypertension in Chinese early-onset hypertensive patients. METHODS: A panel of nine genes, namely SCNN1B, SCNN1G, WNK1, WNK4, KLHL3, CUL3, nuclear receptor subfamily 3, group C (NR3C)1, NR3C2, and HSD11B2 were screened by targeted resequencing in 260 Chinese early-onset hypertensive patients. Additionally, exon 13 of both SCNN1B...

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Identifiers

PMID: 28915228
DOI: 10.1097/HJH.0000000000001556

Genes

CUL3
KLHL3
WNK1
WNK4

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