Article
Genome-wide association study identifies 112 new loci for body mass index in the Japanese population.
Nature genetics - 1 Oct 2017
Akiyama Masato, Okada Yukinori, Kanai Masahiro, Takahashi Atsushi, Momozawa Yukihide, Ikeda Masashi, Iwata Nakao, Ikegawa Shiro, Hirata Makoto, Matsuda Koichi, Iwasaki Motoki, Yamaji Taiki, Sawada Norie, Hachiya Tsuyoshi, Tanno Kozo, Shimizu Atsushi, Hozawa Atsushi, Minegishi Naoko, Tsugane Shoichiro, Yamamoto Masayuki, Kubo Michiaki, Kamatani Yoichiro
Abstract excerpt
Obesity is a risk factor for a wide variety of health problems. In a genome-wide association study (GWAS) of body mass index (BMI) in Japanese people (n = 173,430), we found 85 loci significantly associated with obesity (P < 5.0 × 10-8), of which 51 were previously unknown. We conducted trans-ancestral meta-analyses by integrating these results with the results from a GWAS of Europeans and identified 61...
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