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Article

Inhibition of DYRK1A disrupts neural lineage specificationin human pluripotent stem cells

4 Sept 2017

Abstract excerpt

Genetic analysis has revealed that the dual specificity protein kinase DYRK1A has multiple roles in the development of the central nervous system. Increased DYRK1A gene dosage, such as occurs in Down syndrome, is known to affect neural progenitor cell differentiation, while haploinsufficiency of DYRK1A is associated with severe microcephaly. Using a set of known and newly synthesized DYRK1A inhibitors, along with...

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PMID: 28884684
DOI: 10.7554/elife.24502

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