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Article

Dehydrosqualene Desaturase as a Novel Target for Anti-Virulence Therapy against Staphylococcus aureus.

mBio - 5 Sept 2017

Gao Peng, Davies Julian, Kao Richard Yi Tsun

Abstract excerpt

Staphylococcus aureus, especially methicillin-resistant S. aureus (MRSA), is a life-threatening pathogen in hospital- and community-acquired infections. The golden-colored carotenoid pigment of S. aureus, staphyloxanthin, contributes to the resistance to reactive oxygen species (ROS) and host neutrophil-based killing. Here, we describe a novel inhibitor (NP16) of S. aureus pigment production that reduces the...

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Methicillin-Resistant Staphylococcus aureus
Neutrophils
Oxidoreductases
Pyrrolidines
Staphylococcal Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Staphylococcus aureus

Virulence Factors

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Identifiers

PMID: 28874472
DOI: 10.1128/mBio.01224-17
PMCID: PMC5587911

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