Article
Chronic obstructive pulmonary disease candidate gene prioritization based on metabolic networks and functional information.
PloS one - 1 Jan 2017
Wang Xinyan, Li Wan, Zhang Yihua, Feng Yuyan, Zhao Xilei, He Yuehan, Zhang Jun, Chen Lina
Abstract excerpt
Chronic obstructive pulmonary disease (COPD) is a multi-factor disease, in which metabolic disturbances played important roles. In this paper, functional information was integrated into a COPD-related metabolic network to assess similarity between genes. Then a gene prioritization method was applied to the COPD-related metabolic network to prioritize COPD candidate genes. The gene prioritization method was...
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