Article
Chronic obstructive pulmonary disease candidate gene prioritization based on metabolic networks and functional information.
PloS one - 1 Jan 2017
Wang Xinyan, Li Wan, Zhang Yihua, Feng Yuyan, Zhao Xilei, He Yuehan, Zhang Jun, Chen Lina
Abstract excerpt
Chronic obstructive pulmonary disease (COPD) is a multi-factor disease, in which metabolic disturbances played important roles. In this paper, functional information was integrated into a COPD-related metabolic network to assess similarity between genes. Then a gene prioritization method was appl...
Topics
- Gene Ontology
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Metabolic Networks and Pathways
- Pulmonary Disease, Chronic Obstructive
- ROC Curve
- Reproducibility of Results
- Software