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Article

Comprehensive in situ co-detection of aneuploid circulating endothelial and tumor cells

23 Aug 2017

Abstract excerpt

Abstract Conventional circulating tumor cell (CTC) detection strategies rely on cell surface marker EpCAM and intracellular cytokeratins (CKs) for isolation and identification, respectively. Application of such methods is considerably limited by inherent heterogeneous and dynamic expression or absence of EpCAM and/or CKs in CTCs. Here, we report a novel strategy, integrating antigen-independent subtraction...

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PMID: 28852197
DOI: 10.1038/s41598-017-10763-7

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