Article
Genome organization: connecting the developmental origins of disease and genetic variation.
Journal of developmental origins of health and disease - 1 Jun 2018
Jacobson E, Vickers M H, Perry J K, O'Sullivan J M
Abstract excerpt
An adverse early life environment can increase the risk of metabolic and other disorders later in life. Genetic variation can modify an individual's susceptibility to these environmental challenges. These gene by environment interactions are important, but difficult, to dissect. The nucleus is the primary organelle where environmental responses impact directly on the genetic variants within the genome, resulting...
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